Neurogenic locus notch homolog protein 2 precursor

General Description

Anti-NOTCH2 (Cleaved-Val¹⁶⁹⁷) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Val¹⁶⁹⁷) protein.

Biochem/physiol Actions

The NOTCH2 gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.