Description
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.
1 Oleic acid-
2,6-
diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC
50 of 7 nM.
2 When co-
administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-
2,6-
diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
References
1. Suckling, K.E., and Stange, E.F.
Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism J. Lipid Res. 26(6),647-671(1985).
2. Roth, B.D., Blankley, C.J., Hoefle, M.L., et al.
Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents J. Med. Chem. 35(9),1609-1617(1992).
