N-Arachidonoyl-3-hydroxy-γ-Aminobutyric Acid

Description

Several different arachidonoyl amino acids, including N-arachidonoyl-3-hydroxy-γ-aminobutyric acid (NAG-3H-ABA), have been isolated and characterized from bovine brain.¹ The glycine congener (NAGly; ) was further characterized and found to suppress formalin-induced pain in rats. NAG-3H-ABA was also found in rat brain by LC-MS techniques, but has not been fully characterized to date. Most arachidonoyl amino acids are poor ligands for the CB₁ receptor.

Definition

ChEBI: N-arachidonoyl-3-hydroxy-gamma-aminobutyric acid is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

References

1. Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain J. Biol. Chem. 276(46),42639-42644(2001).