Description
17(S)-
HpDHA is a mono-
oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. 17(S)-
HpDHA is generally reduced to 17(S)-
HDHA , a compound that serves as a precursor to 17(S)-
resolvins. 17(S)-
HDHA has been shown to inhibit TNF-
α-
induced interleukin-
1β expression in human glioma cells and inhibit TNF-
α-
induced leukocyte trafficking to the murine air pouch.
Definition
ChEBI: (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid is a docosanoid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying a hydroperoxy substituent at position 17S. It has a role as a mouse metabolite. It is a docosanoid, a long-chain fatty acid and a hydroperoxy polyunsaturated fatty acid. It is functionally related to an all-cis-docosa-4,7,10,13,16,19-hexaenoic acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate.
