Desfesoterodine (PNU-200577; 5-Hydroxymethyl Tolterodine; 0.1 and 1 mg/kg; IV) significantly increases bladder compliance after moderate and high doses[4].
In vivo, Desfesoterodine is significantly more potent at suppressing acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50=15 and 40 nmol/kg, respectively) [1].
| Animal Model: | Female Sprague Dawley rats at ages 9 to 11 weeks weighing 180 to 250 g[4] |
| Dosage: | 0.1 and 1 mg/kg |
| Administration: | IV; single imidafenacin administration |
| Result: | Significantly increased bladder compliance after moderate and high doses.
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