Chemical Properties
Brown Solid
Uses
A microorganism based antimicrobial with high efficiency, low toxicity and good environmental compatibility. A key effective component of the pesticide M18.
Uses
Tubermycin B (1-phenazinecarboxylic acid) is a simple phenazine produced by several species of Pseudomonas and Actinomycetes. Tubermycin B is a weakly active antibacterial compound that plays a role in the biocontrol of plant diseases by several Pseudomonas strains. Tubermycin B and related phenazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.
Definition
ChEBI: An aromatic carboxylic acid that is phenazine substituted at C-1 with a carboxy group.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 43, p. 1350, 2000
DOI: 10.1021/jm990423f
in vivo
Phenazine-1-carboxylic acid (2 and 3 μg/mL, added through E3 medium, single dose) significantly prevented V. anguillaruminfection in zebrafish embryos[4].
| Animal Model: | Zebrafish embryos infected with Vibrio anguillarum[4] |
| Dosage: | 2 μg/mL and 3 μg/mL |
| Administration: | Added through zebrafish embryo E3 medium, single dose |
| Result: | Effectively inhibited V. anguillarum infection in zebrafish embryos and increased embryo hatching rate. |
