Monoclonal Anti-Pan Cadherin

Uses

Monoclonal Anti-Pan Cadherin antibody produced in mouse has been used in:

• fluorescence imaging
• immunohistochemistry
• western blotting
• immunoblotting
• immunofluorescence

General Description

Neural-cadherin (N-cadherin) is a member of the classic cadherin family. It is mainly expressed in neural and mesenchymal tissues.

Biochem/physiol Actions

Neural-cadherin (N-cadherin) has an oncogenic role in bladder cancer,?breast cancer, prostate cancer and melanoma. It stimulates the heterotypic adhesion of melanoma cells to dermal fibroblast cells. N-cadherin?acts as a critical modulator for the migration of neuronal progenitors. It is essential for the proper cohesion and?polarisation?of?neuroepithelial cells. N-cadherin is important for normal gastrulation and neural crest development. It is required for myogenesis and myotube formation.