Description
Cefaclor was found by Eli Lilly & Co. in 1976 in the course of studies on the improvement of synthetic procedures for cephalexin. The intermediates with chlorine at the 3 position of the cephem nucleus have excellent antibacterial activity. Cefaclor was selected from among the various derivatives that differed at the 7 position because of its strong activity and high bioavailability following oral administration.
Chemical Properties
Crystalline Solid
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
Second-generation cephalosporin antibiotic. Antibacterial.
brand name
Ceclor (Lilly); Raniclor (Ranbaxy).
Contact allergens
Cefaclor is a semisynthetic cephalosporin antibiotic,
related to cefalexin, and a frequent inducer of serum
sickness-like reactions.
