Description
The nucleocapsid proteins of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are viral proteins encoded by the N gene in SARS-CoV and SARS-CoV-2 RNA.1,2 SARS-CoV and SARS-CoV-2 are members of the Betacoronavirus genus of viruses that have approximately 79% sequence identity and share 27 T cell epitopes in common.3,4,5 The SARS-CoV-2 nucleocapsid protein has greater than 90% similarity to the SARS-CoV nucleocapsid protein and contains two unique B cell epitopes and two T cell epitopes that are structurally stable, non-allergenic, and induce production of IFN-γ.2,5 SARS-CoV and SARS-CoV-2 nucleocapsid proteins package the viral RNA into a helical ribonucleoprotein complex (RNP), which is a template for viral replication, and are integral for viral self-assembly and involved in regulation of the cell cycle.2,6 SARS-CoV and SARS-CoV-2 are the causative agents of SARS and COVID-19, respectively, both of which are primarily respiratory illnesses characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.4,7,8 Cayman's SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Rabbit Monoclonal Antibody (Clone 0006-1) can be used for ELISA and ELISA (detection) applications. This recombinant antibody recognizes nucleocapsid protein at 45.6 kDa from SARS-CoV and SARS-CoV-2.WARNING This product is not for human or veterinary use.
