Description
m-PEG4-azide is a PEG reagent with an azide group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry.
Uses
m-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. m-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
References
[1] Belen Begines, et al. Synthesis of Reduction Sensitive Comb-Like Polyurethanes Using Click Chemistry. Journal of Polymer Science Part A: Polymer Chemistry, 2016, 54(24), 3888-3900.
