Chemical Properties
pale yellow to beige powder and granules
Uses
Methyl Vanillate maintains antimicrobial properties due to the phenylpropanoid moiety in the structure.
Uses
Methyl vanillate is used to investigate the volatile compounds of heather honeys from Calluna vulgaris and Erica arborea.
Definition
ChEBI: Methyl vanillate is a benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite. It is a benzoate ester, a member of phenols and an aromatic ether. It is functionally related to a vanillic acid.
General Description
Methyl vanillate is a volatile compound present in cloudberries (Rubus Chamaemorus.). Methyl vanillate can be synthesized from vanillic acid. Methyl vanillate has been identified in foods such as cow's milk and beer.
Biological Activity
Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
References
[1] PU-HYEON CHA. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice.[J]. PLoS ONE, 2014: e85546. DOI:
10.1371/journal.pone.0085546.
[2] ADRIANO DE SOUZA PESSOA . The dimerization of methyl vanillate improves its effect against breast cancer cells via pro-oxidant effect[J]. Chemico-Biological Interactions, 2022, 361: Article 109962. DOI:
10.1016/j.cbi.2022.109962.
[3] CHRONG-SHYUA CHU P. D R C Liao. A formal synthesis of (+/-)-reserpine from methyl vanillate[J]. Chemical Communications, 1996, 1 1: 1537-1538. DOI:
10.1039/CC9960001537.
[4] JUAN TIAN. Ethyl acetate as a co-solvent and sacrificial ester in the aluminum triiodide promoted chemoselective demethylation of methyl vanillate[J]. Tetrahedron Letters, 2017, 58 36: Pages 3522-3524. DOI:
10.1016/j.tetlet.2017.07.089.
