Description
8-
iso PGF
3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-
iso PGF
3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-
iso PGF
2α has an ED
50 value of 1 μM.
1
References
1. Praticò, D., Smith, E.M., Violi, F., et al.
Local amplification of platelet function by 8-epi prostaglandin F2α is not mediated by thromboxane receptor isoforms J. Biol. Chem. 271(25),14916-14924(1996).