Chemical Properties
Purity of the original drug ≥ 96%, its pure product is white to gray crystals, melting point 84 ~ 86 ℃. Vapor pressure 1.0mPa(20℃). Distribution coefficient KowlgP=3.0. relative density 1.311(22℃). Solubility in water 0.016mg/L(25℃);Solubility in other solvents(g/L,25℃):acetone 406,n-alkane 2.3.Stable to light,heat and pH2-7. Hydrolyzed to acid and methanol in alkaline (pH>7).
Production Methods
Flamprop M methyl was produced through a straightforward aryloxyphenoxypropionate assembly, beginning with preparation of the chiral (M)-configured propionate intermediate, typically obtained either by resolution of a racemate or by using an enantioselective catalyst during ester formation. This intermediate was then coupled with the appropriate substituted anilide or phenoxy precursor via controlled esterification or acylation to build the herbicidally active structure. Manufacturers focused on maintaining stereochemical integrity, achieving clean conversion in the coupling step, and purifying the resulting ester to technical grade with tight control of impurities.
Mechanism of action
Selective, systemic, absorbed by leaves
