Description
Fumonisin B
3 (FB
3) is a mycotoxin that has been found in
Fusarium. It is cytotoxic to primary rat hepatocytes when used at concentrations of 125, 250, and 500 μM. Dietary administration of FB
3 (0.05%) for 14 or 21 days induces hepatocyte nodules, a marker of cancer initiation, in rats. FB3 has been detected in corn and corn-based foods and livestock feeds.
Uses
Fumonisin B3 is a mycotoxin present in corn. Fungal metabolite believed to cause leukoencephalomalacia in horses.
References
[1] J. RHEEDER H V W Marasas. Production of Fumonisin Analogs by Fusarium Species[J]. Applied and Environmental Microbiology, 2002, 68 1: 2101-2105. DOI:
10.1128/aem.68.5.2101-2105.2002[2] W.C.A. GELDERBLOM . Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assays[J]. Food and Chemical Toxicology, 1993, 31 6: Pages 407-414. DOI:
10.1016/0278-6915(93)90155-r[3] BULLERMAN L B. Occurrence of Fusarium and fumonisins on food grains and in foods.[J]. Advances in experimental medicine and biology, 1996, 392: 27-38. DOI:
10.1007/978-1-4899-1379-1_3
