Chemical Properties
clear colorless liquid
Uses
Tetramethylstannane is used in preparation of Biphenyl Pyrazines as PD-1/PD-L1 inhibitors for treating cancer.
Uses
Tetramethyltin is used in many organic syntheticreactions.
Definition
ChEBI: An organotin compound carrying four methyl groups.
Health Hazard
Tetramethyltin is moderately toxic by allroutes of exposure. The symptoms includeheadache, muscle weakness, and paralysis.Exposure limits:
TLV-TWA: 0.1 mg (Sn)/m
3 (skin) (ACGIH)
PEL-TWA: 0.1 mg (Sn)/m
3 (skin) (OSHA).
Fire Hazard
The ease of oxidation, however, is low in
comparison with most other metal alkyls. It
is relatively stable to air and does not ignite spontaneously as other alkyls do. Also, it
is stable in water. The compound, however,
is highly flammable, the flash point being
( －13°C) 9°F (Aldrich 1996). It explodes
violently in contact with dinitrogen tetraoxide
even, at －80°C (－112°F) (Bailar 1973).
Reaction with strong oxidizers is expected to
be vigorous to violent.
Safety Profile
Moderately toxic by inhalation. A very dangerous fire and explosion hazard when exposed to heat, flame, or oxidizers. Powerful explosive reaction with dinitrogen tetroxide. To fight fire, use water, foam, CO2, dry chemical. When heated it emits acrid smoke and irritating fumes. See also TIN COMPOUNDS and ORGANOMETALS.
Purification Methods
It is purified by fractionation using a Todd column (p 11) of 35-40 plates at atmospheric pressure. The purity of the fractions can be followed by IR [Edgell & Ward J Am Chem Soc 77 6486 1955]. It readily dissolves stopcock silicone greases which give bands in the 8-10a region. [Edgell & Ward J Am Chem Soc 76 1169 1954, Beilstein 4 IV 4307.]
