Bimagrumab
- Product NameBimagrumab
- CAS1356922-05-8
- CBNumberCB08080877
- MW0
- MOL FileMol file
- MSDS FileSDS
Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
| FDA UNII | N15SW1DIV8 |
| NCI Drug Dictionary | bimagrumab |
Bimagrumab Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0621493 | 1mg | $433 | Bimagrumab 99.31% |
Buy |
| ChemScene CS-0621493 | 5mg | $1083 | Bimagrumab 99.31% |
Buy |
| ChemScene CS-0621493 | 10mg | $1733 | Bimagrumab 99.31% |
Buy |
| ChemScene CS-0621493 | 25mg | $3142 | Bimagrumab 99.31% |
Buy |
| Biorbyt Ltd orb1290220 | 100μg | $200 | Bimagrumab >95% |
Buy |
Bimagrumab Chemical Properties,Usage,Production
Uses
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness[1][2].in vivo
BYM338 (6-20 mg/kg; s.c. once weekly for 4 weeks) promotes an increase in body weight and skeletal muscle hypertrophy of all examined muscles, slow, fast, and mixed of young SCID mice[2].
BYM338 (5-20 mg/kg; s.c. once weekly for 14 d) prevents Glucocorticoid-induced muscle wasting in mice[2].
IC 50
ACVR2B: 1.7 pM (Kd); ACVR2A: 434 pM (Kd)References
[1] Heymsfield SB, et, al. Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial. JAMA Netw Open. 2021 Jan 4;4(1):e2033457. DOI:10.1001/jamanetworkopen.2020.33457[2] Lach-Trifilieff E, et, al. An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy. Mol Cell Biol. 2014 Feb;34(4):606-18. DOI:10.1128/MCB.01307-13
Preparation Products And Raw materials
Bimagrumab Suppliers
Global(23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 18007167883 18007167883 |
Service@mabnus.com | China | 921 | 58 | |
| 15817493340 | 981810490@qq.com | China | 1577 | 58 | |
| 027-65317797 15926423062 |
422450190@qq.com | China | 10302 | 58 | |
| 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 | |
| 027-65279366 18108604356 |
products@biolabreagent.com | China | 9864 | 58 | |
| 13720134139 086-15871494362 13720134139 |
orders@jknbiochem.com | China | 7284 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 | |
| 027-027-16602739303 16602739303 |
673003916@qq.com | China | 4622 | 58 | |
| 6206333 13167063860 |
anhua.mao@aladdin-e.com | China | 49394 | 58 | |
| 15111215862 18229892877 |
3062105966@qq.com | China | 5571 | 58 |
1356922-05-8, BimagrumabRelated Search
PROMPT×
PROMPT
The WhatsApp is temporarily not supported in mainland China
The WhatsApp is temporarily not supported in mainland China
Cancel
Determine