Synthesis
3,4-Dimethylthiophene can be prepared from tetraethoxycarbonylethane and dichloromethyl sulfide. The ester is reduced with LAH to give a diol, and the diacetate is directly pyrolyzed to give 3,4-dimethylthiophene.
Uses
3,4-Dimethylthiophene is used in dry onion preparation for seasoning.
Definition
ChEBI: 3,4-dimethylthiophene is a thiophene that is substituted by methyl groups at positions 3 and 4. It has a role as a flavouring agent, a plant metabolite and a human urinary metabolite.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 869, 1962
DOI: 10.1021/jo01050a043
