Description
Sulfacetamide is a sulfonamide antibiotic that is bacteriostatic against Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (IC
50 = 9.6 μM), blocking the synthesis of dihydrofolic acid, and also inhibits bacterial 4-aminobenzoic acid , which is required for the synthesis of folic acid.
Chemical Properties
White crystalline powder, melting point 183°C. Freely soluble in water, slightly soluble in ethanol, slightly soluble in acetone. No stink bugs, slightly bitter taste.
Uses
Sulfacetamide Sodium Salt is an antibiotic that blocks synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. It can be used in biological study to explore topical application of benzoyl peroxide, antibiotics, sulfur and sodium sulfacetamide, azelaic acid for treatment of acne vulgaris in humans.
Uses
Sulfacetamide Sodium is an anti-biotic
Definition
ChEBI: An organic sodium salt that is the monosodium salt of sulfacetamide.
brand name
Bleph (Allergan); Cetamide (Alcon); Klaron (Sanofi Aventis); Ocusulf (MIZA); Sodium Sulamyd (Schering); Sulf (Novartis); Sulfacel (Optopics); Sulfair (Pharmafair); Sulten (Bausch & Lomb).
References
[1] VIKRAM PRABHU John K Helen Lui. Arabidopsis dihydropteroate synthase: General properties and inhibition by reaction product and sulfonamides[J]. Phytochemistry, 1997, 45 1: Pages 23-27. DOI:
10.1016/s0031-9422(96)00793-5
