PF-00356231 hydrochloride

Biological Activity

PF-00356231 hydrochloride is a non-peptide, non-zinc-chelating matrix metalloprotease MMP-12 ligand and inhibitor (IC50=1.4 μM). It is specific for MMP-12 and forms the PF-00356231/MMP-12 complex.

in vitro

target

MMP-12 < span> 1.4 μM (IC 50 )

MMP13 0.65 nM (IC 50 )

MMP-3 < span> 0.39 μM (IC 50 )

MMP-8 1.7 μM (IC 50 )

MMP-9 0.98 μM (IC 50 )