Description
Rilpivirine-d6 is intended for use as an internal standard for the quantification of rilpivirine (Item No. 21559) by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM.1 It is active against NNRTI-resistant HIV strains with EC50 values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = <10 nM), including strains containing up to eight resistance mutations. In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Item No. 18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.2WARNING This product is not for human or veterinary use.
References
[1] LUCY GARVEY Alan W. Rilpivirine: a novel non-nucleoside reverse transcriptase inhibitor.[J]. Expert opinion on investigational drugs, 2009, 18 7: 1035-1041. DOI:
10.1517/13543780903055056[2] MARILUZ ARAÍNGA. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy.[J]. Retrovirology, 2017: 17. DOI:
10.1186/s12977-017-0344-7
