Description
Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages.
1,2 DHA is oxidized to maresin 1 (MaR1; ), which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C
4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase.
3 MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1.
2 Pretreatment with MCTR3 prior to
E. coli administration in mice reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of
E. coli by macrophages. When administered at a dose of 100 ng 12h post
E. coli infection in a mouse model of peritonitis, MCTR3 selectively reduces the amount of the eicosanoids PGD
2 , PGE
2 , PGF
2α , and TXB
2 in the exudate.
References
1. Serhan, C.N.
Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology Nature 510(7503),92-101(2014).
2. Dalli, K.J., Sanger, J.M., Rodriguez, A.R., et al.
Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3 PLoS One 11(2),e0149319(2016).
3. Dalli, J., Vlasakov, I., Riley, I.R., et al.
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. USA 113(43),12232-12237(2016).
