Originator
Tolperisone hydrochloride,Shanghai Abochem
Chemical Co.
Definition
ChEBI: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone.
Manufacturing Process
To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added
an excess of thionyl chloride and the reaction mixture refluxed until
completed. It was then taken to dryness under reduced pressure and the
residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate.
An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine
hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered
palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone
was purified by distilling the base (boiling point 106-107°C/1 mm) and
reconverting to the hydrochloride, melting point 216-217°C.
brand name
Tolperisone Hydrochloride
is JAN.
Therapeutic Function
Muscle relaxant, Vasodilator
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994
DOI: 10.1248/cpb.42.1676
