4-arM Poly(ethylene glycol)

Description

4-Arm PEG-OH is a multi-arm polyethylene glycol with hydroxyl groups at each terminal of the four arms. Pentaerythritol core is used in 4arm PEG raw materials and derivatives. The indicated molecular weight of the multi-arm PEG is the sum of the molecular weights of all the arms.

Chemical Properties

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

Uses

4-arM Poly(ethylene glycol) is a multi-armed PEG reagent with 4 reactive groups for PEGylation, hydrogels, crosslinking, coating, nanoparticles, and polymer-drug conjugates. Applications include tissue engineering, drug delivery formulations, diagnostic assays, and pharmaceutical and cosmetic R&D.

Application

4-arM Poly(ethylene glycol) can be used to prepare bean-cleavable 4-arm poly(ethylene glycol)-adriamycin couplings which are used for tumour-specific delivery and release.