Chemical Properties
solid
Uses
2-Methyl-4(5)-nitroimidazole was used to study the mechanism of both the alkaline and acidic hydrolysis of tinidazole.
Uses
Floconazole impurity.
Definition
ChEBI: 2-Methyl-5-nitroimidazole is a C-nitro compound and a member of imidazoles.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Synthesis
General procedure for the synthesis of 2-methyl-4-nitroimidazole from 4-iodo-2-methyl-5-nitro-1H-imidazole: (1) In a 5 mL microreaction flask, 50 mg of 4-bromo-2-methyl-5-nitroimidazole prepared in Example 1 was added, followed by the addition of 3 mL of methanol to dissolve it completely. Then, 5 mg of 10% palladium carbon (Pd/C) was added as a catalyst. The reaction flask was placed on a hydrogenation unit and high purity hydrogen was passed through, displacing it three times to ensure that the reaction system was free of oxygen. The reaction pressure was adjusted to 100 mmHg and the reaction was stirred at 25 °C for 30 h. The reaction pressure was adjusted to 100 mmHg. Upon completion of the reaction, the Pd/C catalyst was removed by centrifugation and the remaining liquid was concentrated by evaporation under reduced pressure to obtain the target product 2-methyl-5-nitroimidazole. The yield of this step was 47% by HPLC analysis.
References
[1] Patent: CN106674123, 2017, A. Location in patent: Paragraph 0039; 0040
