Description
S-
Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found
in vivo include proteins such as S-
nitrosohemoglobin and S-
nitrosoalbumin, as well as low molecular weight species such as S-
nitrosoglutathione (GSNO) and S-
nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-
nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-
life of one minute in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-
constricted rat aortic strips 59% and 16% at pH 6.0 and 7.4, respectively.
