Description
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-
HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-
HETE is stereospecific. 16(R)-
HETE dose-
dependently stimulates vasodilation of the rabbit kidney, however 16(S)-
HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-
enantiomer of 16-
HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-
isomer has negligible effects on ATPase activity.
