Diacetato{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}ruthenium(II) Ru(OAc)2[(R)-dm-segphos]　

Reaction

1. Biaryl bisphosphine ligand with narrow dihedral angle. The DM-SEGPHOS ligand, as the ruthenium complex, gives superior enantioselectivity and diastereoselectivity in the asymmetric hydrogenation of α-substituted-β-ketoesters.
2. Ruthenium catalyzed enantioselective synthesis of β amino acids by hydrogenation.
3. Ruthenium catalyzed asymmetric hydrogenation of 3-quinuclidinone.

Uses

• The enantioselective asymmetric hydrogenation reaction.
• The asymmetric reductive amination reaction.
• The total synthesis of (-)-tubingensin B via Suzuki-Miyaura coupling and aryne cyclization reactions.