Description
A pregnene alkaloid found in the bark of Holarrhena antidysenterica Wall. and
also present in the leaves of Sarcococca pruni!ormis Lindl., the base forms colour_x0002_less crystals from Me2CO and has [α]
20D - 37° (c 1.90, CHCl3), - 17° (c 1.OS,
MeOH). It contains three methyl groups and two dimethylamino groups in the
molecule. The alkaloid is characterized as the crystalline perchlorate, m.p. 277-
9°C (dec.) or the picrate, m.p. 228-230°C. The structure has been established as
3 ,20 -bis (dimethylamino)pregn-S-ene. It is identical with saracodinine.
References
Tschesche, Wiensz., Chem. Ber., 91, lS04 (19S8)
Tschesche, Otto., ibid, 95, 1144 (1962)
Chatterjee et aI., Tetrahedron Lett., 67 (1965)
Structure:
Labler, Sorm., Collect. Czech. Chem. Commun., 28,2345 (1963)
