Uses
ANTI-FKBP9(C-TERMINAL) antibody produced in rabbit is suitable for flow cytometry (1:10-1:50), immunohistochemistry (1:50-1:100) and western blot (1:1000).
General Description
FKBP9 (FK506 binding protein 9, 63kDa) is a 63kDa protein belonging to the FKBP gene family. It possesses structural similarities with FKBP65 and SMAP. The protein is expressed in heart, skeletal muscle, lung, liver, and kidney. It consists of a hydrophobic region at the N-terminus, four peptidyl-prolyl cis/trans isomerase (PPIase) domains and an endoplasmic reticulum retention motif (HDEL) at the C-terminal end. FKBP9 accelerates isomerization activity of the peptidyl-prolyl bond via its C-terminal EF-hand Ca
2+ binding motif.
Description
FKBP1B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-108) and having a molecular mass of 14.2kDa.
FKBP1B is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Background
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 and rapamycin. FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.
