Description
20-
carboxy Arachidonic acid (20-
COOH-
AA) is the major metabolite of 20-
HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-
oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-
HETE, 20-
COOH-
AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-
COOH-
AA binds to isolated ligand binding domains of peroxisome proliferator-
activated receptor α (PPARα) (K
d = 0.87 ± 0.12 μM) and PPARγ (K
d = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-
7 cell reporter system.
Definition
ChEBI: An alpha,omega-dicarboxylic acid that is (5Z,8Z,11Z,14Z)-icosatetraene in which the two methyl groups are replaced by carboxy groups.
