1-Methoxy-2-methyl-2-propanol

Synthesis

558-30-5

67-56-1

3587-64-2

1. Catalyst pretreatment: 0.037 mmol of Zr catalyst was added to a 25 mL round-bottomed flask and heated at 150°C under vacuum overnight to remove the absorbed water. 2. Reaction system preparation: 5mL of methanol was added to the flask and sonicated for 15 min. 3. Addition of reactants: 1 mmol of propylene oxide was added. 4. 4. Reaction condition setting: Place the reaction mixture in a bath preheated to 50°C with magnetic stirring. 5. Catalyst activation (if applicable): 2.5 mL of acetone was added as solvent and after sonication of the catalyst, 1.0 mmol of amine and 1.0 mmol of styrene oxide were added sequentially. 6. Reaction termination and product recovery: At the end of the reaction, the catalyst was washed thoroughly with methanol to recover the adsorbed products. 7. Product purification: The product was purified using silica gel. 7. Product purification: The product was purified by rapid column chromatography using silica gel column chromatography with hexane:methylene chloride as eluent. 8. Reaction monitoring: Aliquots of the reaction mixture were withdrawn periodically with a syringe, diluted with methanol and immediately analyzed by GC (Agilent 6890 network GC system), and the product concentration was determined by a calibration curve.

References