Description
Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as AKT and phosphatidylinositol 3,4,5-
trisphosphate (PIP
3). PTEN interacts with many other proteins to regulate cell division and migration, as well as promoting apoptosis when necessary. Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma, making PTEN an important tumor suppressor. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.
References
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10.1016/s0092-8674(00)80674-1[2] IGOR VIVANCO Charles L S. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer[J]. Nature Reviews Cancer, 2002, 2 7: 489-501. DOI:
10.1038/nrc839[3] DAHIA P L. PTEN, a unique tumor suppressor gene.[J]. Endocrine-related cancer, 2000, 7 2: 115-129. DOI:
10.1677/erc.0.0070115[4] PETER A. STECK. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers[J]. Nature genetics, 1997, 15 4: 356-362. DOI:
10.1038/ng0497-356
