Description
Artemisinin-d
3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various
P. falciparum strains
in vitro (IC
50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with
P. falciparum with a curative dose (CD
50) value of 140 mg/kg. It also reduces
P. berghei infection in mice (ED
50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G
0/G
1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
Uses
Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial
