Chlormerodrin

chlormerodrin Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Neohydrin,Lakeside,US,1952

• Verwenden

  Chlormerodrin is a sulfhydryl blocking agent; using NK cells, particularly CAR-modified NK cells, for producing induced cellular vesicles (ICVs) loaded with chemotherapeutic agent(s) for cancer therapy.

• Definition

  ChEBI: Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.

• Manufacturing Process

  To a refluxing solution of 100 g of allyl urea and 600 ml of absolute methanol there was added with stirring a suspension of 319 g of mercuric acetate and 600 ml of absolute methanol and 60 ml of glacial acetate acid; complete solution resulted. After 6 hours of refluxing, the solution was cooled and clarified by filtration. To this solution there were added 50 g of sodium chloride and 240 ml of water. After a short time a heavy white precipitate settled out. This precipitate, which was 3-chloromercuri-2-methoxypropylurea, was filtered, washed and dried.

• Trademarks

  Mercloran (Parke-Davis); Neohydrin (Marion Merrell Dow).

• Therapeutic Function

  Diuretic

chlormerodrin Upstream-Materialien And Downstream Produkte

Chlormerodrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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