DILEVALOL

DILEVALOL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Dilevalol is a "dual-mechanism" antihypertensive reportedly suitable for a wide range of patients. Its partial beta2-agonist action is expected to induce vasodilation, whereas its beta1-antagonist component may protect against stress-induced hemodynamic charges without altering the cardiac output. Dilevalol is the R,R-isomer of labetalol.

• Originator

  Schering Plough (USA)

• Verwenden

  Specific competitive antagonist at both α-and β-adrenergic receptor sites. Antihypertensive.

• Verwenden

  (R,R)-Labetalol is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol is used as an antihypertensive.

• Definition

  ChEBI: (R,R)-labetalol is a 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide that has 1R,2R-configuration. It is a conjugate base of a dilevalol(1+).

• Trademarks

  Levadil; Dilevalon

• Weltgesundheitsorganisation (WHO)

  Dilevalol, a beta-adrenoreceptor antagonist, was introduced into medicine in 1989 for the treatment of hypertension. Shortly afterwards, its use became associated with isolated cases of hepatic toxicity. Although few cases were reported, the manufacturer discontinued sales in Japan and Portugal, the only countries where the drug was marketed, and withdrew applications for registration elsewhere.

DILEVALOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(19)Suppliers

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