N-(4-Chlorphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid

NAPHTHOL AS-E PHOSPHATE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

• Biologische Aktivität

  Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

• in vitro

  Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

• in vivo

  Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

• target

  N-(4-Chlorphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  18228-17-6, NAPHTHOL AS-E PHOSPHATE Verwandte Suche:

  • N-(4-Chlorphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid
  • 4'-Chlor-3-hydroxy-2-naphthanilid
  • Dinatrium-7-brom-N-(2-methoxyphenyl)-3-(phosphonatooxy)naphthalin-2-carboxamidat
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  • N-(3-Nitrophenyl)-3-(phosphonooxy)naphthalin-2-carboxamid

  • N-(5-Chlor-2-methoxyphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid
  • 3-(Phosphonooxy)-N-(o-tolyl)naphthalin-2-carboxamid
  • 3-(Phosphonooxy)-N-(2,4-xylyl)naphthalin-2-carboxamid
  • N-(4-Chlor-2-methylphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid
  • N-(4-Chlor-2,5-dimethoxyphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid

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