N-(4-Chlorphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid

NAPHTHOL AS-E PHOSPHATE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

• in vitro

  Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

• in vivo

  Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

• target

  N-(4-Chlorphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

  Global(76)Suppliers

  Region

  China 56 Czech Republic 1 Germany 1 India 1 Switzerland 1 United Kingdom 4 United States 12

  Clear All Done

  • ATK CHEMICAL COMPANY LIMITED

    Telefon +undefined-21-51877795

    E-Mail ivan@atkchemical.com

  • Biochempartner

    Telefon 0086-13720134139

    E-Mail candy@biochempartner.com

  • BOC Sciences

    Telefon +1-631-485-4226

    E-Mail inquiry@bocsci.com

  • HANGZHOU CLAP TECHNOLOGY CO.,LTD

    Telefon 86-571-88216897,88216896<br/>13588875226

    E-Mail sales@hzclap.com

  • Zhejiang J&C Biological Technology Co.,Limited

    Telefon +1-2135480471<br/>+1-2135480471

    E-Mail sales@sarms4muscle.com

  • InvivoChem

    Telefon +1-708-310-1919<br/>+1-13798911105

    E-Mail sales@invivochem.cn

  • Hangzhou MolCore BioPharmatech Co.,Ltd.

    Telefon +86-057181025280;<br/>+8617767106207

    E-Mail sales@molcore.com

  • Nantong HI-FUTURE Biology Co., Ltd.

    Telefon +undefined18051384581

    E-Mail sales@chemhifuture.com

  • TargetMol Chemicals Inc.

    Telefon +1-781-999-5354

    E-Mail support@targetmol.com

  • LEAPCHEM CO., LTD.

    Telefon +86-852-30606658

    E-Mail market18@leapchem.com

  1of2

  18228-17-6, NAPHTHOL AS-E PHOSPHATE Verwandte Suche:

  • N-(4-Chlorphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid
  • 4'-Chlor-3-hydroxy-2-naphthanilid
  • Dinatrium-7-brom-N-(2-methoxyphenyl)-3-(phosphonatooxy)naphthalin-2-carboxamidat
  • 6-Brom-3-(o-hydroxyphenylaminocarbonyl)-2-naphthylphosphat
  • N-(3-Nitrophenyl)-3-(phosphonooxy)naphthalin-2-carboxamid

  • N-(5-Chlor-2-methoxyphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid
  • 3-(Phosphonooxy)-N-(o-tolyl)naphthalin-2-carboxamid
  • 3-(Phosphonooxy)-N-(2,4-xylyl)naphthalin-2-carboxamid
  • N-(4-Chlor-2-methylphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid
  • N-(4-Chlor-2,5-dimethoxyphenyl)-3-(phosphonooxy)naphthalin-2-carboxamid

  1of2

  Send Inquriy
  Website-Startseite| CAS| Die PC-Version
  Chemical Book

  Target	Value
  CREB ()