D-Glucuronsäure, gamma-Lacton

Bezeichnung:D-Glucuronsäure, gamma-Lacton

CAS-Nr32449-92-6

Englisch Name:D-Glucurone

CBNumberCB9718232

SummenformelC6H8O6

Molgewicht176.12

MOL-Datei32449-92-6.mol

Synonyma

Glucurolacton

D-Glucuronsäure, gamma-Lacton

D-Glucuronsäure, gamma-Lacton physikalisch-chemischer Eigenschaften

Schmelzpunkt	172-175 °C (lit.)
Siedepunkt	227.71°C (rough estimate)
alpha	19 º (c=10, H2O)
Dichte	1,76 g/cm³
Brechungsindex	18.5 ° (C=5, H2O)
storage temp.	Store below +30°C.
Löslichkeit	water: soluble25mg/mL, clear, colorless
Aggregatzustand	Crystals or Crystalline Powder
pka	11.96±0.60(Predicted)
Farbe	White
Geruch (Odor)	at 100.00 %. very mild mentholic
Geruchsart	mentholic
Optische Rotation	[α]24/D +18.8°, c = 8 in H2O
Wasserlöslichkeit	SOLUBLE
Merck	14,4467
BRN	83595
Major Application	clinical testing
Kosmetik-Inhaltsstoffe Funktionen	SKIN CONDITIONING
InChI	1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
InChIKey	OGLCQHRZUSEXNB-IEPORWDDSA-N
SMILES	O=C([C@@H]([C@@H](O1)[C@H](O)[C@H](O)C1=O)O)[H]
LogP	-3.457 (est)
CAS Datenbank	32449-92-6(CAS DataBase Reference)
EPA chemische Informationen	D-Glucuronolactone (32449-92-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26
WGK Germany	2
RTECS-Nr.	LZ8930000
TSCA	TSCA listed
HS Code	2932209090
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

D-Glucurone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystals or crystalline powder
Verwenden
D-Glucurone is a glucuronic acid derivative. It is used for treating canine hepatitis.
Verwenden
D-Glucurono-6,3-lactone is a glucuronic acid derivative studied for its effectiveness against canine hepatitis. It is utilized in the studies such as starting regent in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, required for the preparation of 1-O-acyl glucuronide of the anti-inflammatory drug ML-3000, synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides.
Definition
The γ-lactone of glucuronic acid. Found in plant gums and animal connective tissues.
Allgemeine Beschreibung
D-(+)-Glucuronic acid γ-lactone (Glucourono-γ-lactone, Glucurone or Glycurone) is a carbohydrate derivative. It converted into L-ascorbic acid in animals and human body. Its molecule contains two five-membered rings. Its crystal structure has been studied.
läuterung methode
Dissolve the lactone or mixture of lactone and acid in H2O and concentrate on a steam bath until crystallisation begins. Cool rapidly to room temperature wih stirring. After 2hours the product is filtered off, washed with cold EtOH and dried to m 174-175o and [] D +19.8o (c 5.2, H2O). The amount of free acid can be obtained by titration of an ice-cold aqueous solution with standard alkali. It can be recrystallised from EtOH, EtOH/H2O or MeOH, and the highest recorded m is 180o. [Stacey J Chem Soc 1529 1939, Mehltretter et al. J Am Chem Soc 73 2424 1951, Beilstein 18 III/IV 3055, 18/5 V 33.]

D-Glucurone Upstream-Materialien And Downstream Produkte

D-Glucuronsäure, gamma-Lacton Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

32449-92-6, D-Glucurone Verwandte Suche:

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