6-IODONORDIHYDROCAPSAICIN

Bezeichnung:6-IODONORDIHYDROCAPSAICIN

CAS-Nr859171-97-4

Englisch Name:6-IODONORDIHYDROCAPSAICIN

CBNumberCB9673887

SummenformelC17H26INO3

Molgewicht419.3

MOL-Datei859171-97-4.mol

6-IODONORDIHYDROCAPSAICIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	106-107 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Siedepunkt	552.9±50.0 °C(Predicted)
Dichte	1.375±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	H₂O: insoluble
Aggregatzustand	solid
pka	8.93±0.25(Predicted)
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

6-IODONORDIHYDROCAPSAICIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
6-?iodonordihydrocapsaicin (6-?I-?CPS) is a weak ERα agonist. It was demonstrated to induce luciferase gene expression.
Definition
ChEBI: N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide is a member of phenols and a member of methoxybenzenes.
Biologische Aktivität
the vanilloid trpv1 receptor, also known as vr1 receptor, belongs to the large family of ‘transient receptor potential’ (trp). trpv1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the c and ad type. 6-iodo-nordihydrocapsaicin is a potent trpv1 antagonist.
in vitro
using human recombinant trpv1, 6-iodonordihydrocapsaicin (ic50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical trpv1 antagonist, capsazepine [1].
in vivo
6-iodonordihydrocapsaicin was tested against capsaicin also on native trpv1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. in all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a trpv1 antagonist [1].
IC 50
10 nm against 100 nm capsaicin
Einzelnachweise
[1] appendino g, harrison s, de petrocellis l, daddario n, bianchi f, schiano moriello a, trevisani m, benvenuti f, geppetti p, di marzo v. halogenation of a capsaicin analogue leads to novel vanilloid trpv1 receptor antagonists. br j pharmacol. 2003 aug;139(8):1417-24.

6-IODONORDIHYDROCAPSAICIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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