IONOMYCIN CALCIUM SALT Struktur

IONOMYCIN CALCIUM SALT

Bezeichnung:IONOMYCIN CALCIUM SALT

CAS-Nr56092-82-1

Englisch Name:IONOMYCIN CALCIUM SALT

CBNumberCB9458893

SummenformelC41H70CaO9

Molgewicht747.07

MOL-Datei56092-82-1.mol

IONOMYCIN CALCIUM SALT physikalisch-chemischer Eigenschaften

Schmelzpunkt	205-206 C
Flammpunkt	87 °C
storage temp.	−20°C
Löslichkeit	Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
Aggregatzustand	White to off-white solid
Farbe	white to off-white
Sensitive	Light Sensitive
BRN	1416163
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	NO0650000
HazardClass	3
HS Code	29419090

Gefahreninformationscode (GHS)

IONOMYCIN CALCIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.
Chemische Eigenschaften
Powder
Verwenden
Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.
Verwenden
Ionomycin is more effectivethan A23187 as a Ca++ionophore; Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons.
Allgemeine Beschreibung
Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).
Biologische Aktivität
Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).
Biochem/physiol Actions
Product does not compete with ATP.
Lager
-20°C
Einzelnachweise
Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815 Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892

IONOMYCIN CALCIUM SALT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

56092-82-1, IONOMYCIN CALCIUM SALT Verwandte Suche:

Send Inquriy