BTS Struktur

BTS

Bezeichnung:BTS

CAS-Nr1576-37-0

Englisch Name:BTS

CBNumberCB9457528

SummenformelC14H15NO2S

Molgewicht261.34

MOL-Datei1576-37-0.mol

BTS physikalisch-chemischer Eigenschaften

Schmelzpunkt	115 °C
Siedepunkt	419.1±48.0 °C(Predicted)
Dichte	1.204±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Dichloromethane, Ethyl Acetate (Slightly)
Aggregatzustand	White crystalline solid
pka	11.54±0.30(Predicted)
Farbe	White to Off-White
Sensitive	Light Sensitive
CAS Datenbank	1576-37-0(CAS DataBase Reference)

Sicherheit

RTECS-Nr.	XT5490000
HS Code	2935.90.9500
Toxizität	rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 41, 1953.

Gefahreninformationscode (GHS)

BTS Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
BTS is an inhibitor of skeletal muscle myosin II ATPase activity that reduces the affinity of ADP-myosin for actin. It inhibits calcium-stimulated ATPase activity of rabbit muscle myosin subfragment 1 (S1) in an actin-independent manner with an IC₅₀ value of approximately 5 μM. It is selective for calcium-stimulated myosin II over human platelet myosin II, kinesin, pyruvate kinase, and lactate dehydrogenase at 100 μM. BTS (2 μM) inhibits the activity of skeletal muscle myosin, reversibly reducing the sliding velocity of heavy meromyosin in a gliding-filament assay. It inhibits isometric calcium-activated tension in isolated fast-twitch rabbit psoas muscle fibers (IC₅₀ = ~3 μM) but not in isolated slow-twitch rat trabeculae and papillary cardiac muscle. BTS is also an intermediate in the synthesis of sulfonamides.
Chemische Eigenschaften
White Solid
Verwenden
A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin interaction with F-actin. Does not affect platelet myosin II
Verwenden
A potent inhibitor of calcium-stimulated myosin S1 ATPase
Definition
ChEBI: 4-methyl-N-(phenylmethyl)benzenesulfonamide is a sulfonamide.
Synthesis Reference(s)
The Journal of Organic Chemistry, 28, p. 592, 1963 DOI: 10.1021/jo01037a523
Biologische Aktivität
Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC 50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.
Lager
Desiccate at RT

BTS Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1576-37-0, BTS Verwandte Suche:

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