16,16-DIMETHYL PROSTAGLANDIN E2

Bezeichnung:16,16-DIMETHYL PROSTAGLANDIN E2

CAS-Nr39746-25-3

Englisch Name:16,16-DIMETHYL PROSTAGLANDIN E2

CBNumberCB9416741

SummenformelC22H36O5

Molgewicht380.52

MOL-Datei39746-25-3.mol

16,16-DIMETHYL PROSTAGLANDIN E2 physikalisch-chemischer Eigenschaften

Flammpunkt	-13℃
storage temp.	-20°C
Löslichkeit	Soluble in methyl acetate
Aggregatzustand	methyl acetate solution
Farbe	Colorless to light yellow

Sicherheit

Kennzeichnung gefährlicher	F,Xn,Xi
R-Sätze:	11-20/21/22-36/37/38-67-66-36
S-Sätze:	16-26-36
RIDADR	UN 1231 3/PG 2
WGK Germany	3

Gefahreninformationscode (GHS)

16,16-DIMETHYL PROSTAGLANDIN E2 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
16,16-dimethyl PGE₂ is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE₂ acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs. The K_d for activation of isolated EP₂ receptors is about 1 nM. 16,16-dimethyl PGE₂ can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.
Definition
ChEBI: 16,16-dimethylprostaglandin E2 is a prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. It has a role as a radiation protective agent, an anti-ulcer drug and a gastrointestinal drug. It is a prostanoid, a monocarboxylic acid, a secondary allylic alcohol and a member of cyclopentanones.
in vitro
dmpge2 was reported to cause an increase in runx11/cmyb1 hscs, while hscs were inhibited by indomethacin treatment in 90% of embryos. moreover, dmpge2 had minimal effects on the vasculature, while indomethacin altered the intersomitic vessels slightly. imaged by confocal microscopy, red-labelled hscs and endothelium embryos showed significantly increased hscs following dmpge2 exposure [1].
in vivo
in a heterotopic model of rat allograft rejection, dmpge2 could delay the rejection onset, but all animals developed severe rejection and died subsequently. treatment of animals with low-dose csa in combination with dmpge2 led to a delay in the onset as well as a reduction in the intensity of allograft rejection. in addition, a statistical relationship between procoagulant activity levels and the time of onset of rejection was observed [1].
Lager
Store at -80°C
Einzelnachweise
[1] north te,goessling w,walkley cr,lengerke c,kopani kr,lord am,weber gj,bowman tv,jang ih,grosser t,fitzgerald ga,daley gq,orkin sh,zon li. prostaglandin e2 regulates vertebrate haematopoietic stem cell homeostasis. nature.2007 jun 21;447(7147):1007-11.
[2] koh ih,kim pc,chung sw,waddell t,wong py,gorczynski r,levy ga,cohen z. the effects of 16, 16 dimethyl prostaglandin e2 therapy alone and in combination with low-dose cyclosporine on rat small intestinal transplantation. transplantation.1992 oct;54(4):592-8.

16,16-DIMETHYL PROSTAGLANDIN E2 Upstream-Materialien And Downstream Produkte

16,16-DIMETHYL PROSTAGLANDIN E2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Send Inquriy