5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4

• Chemische Eigenschaften

  White Solid

• Verwenden

  Secondary metabolite of Cholesterol.

• Definition

  ChEBI: The 7alpha-hydroxy derivative of cholesterol.

• Einzelnachweise

  1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Upstream-Materialien And Downstream Produkte

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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