Y16 Struktur

Y16

Bezeichnung:Y16

CAS-Nr429653-73-6

Englisch Name:Y16

CBNumberCB92735545

SummenformelC24H20N2O3

Molgewicht384.43

MOL-Datei429653-73-6.mol

Y16 physikalisch-chemischer Eigenschaften

Dichte	1.273±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble5mg/mL, clear (warmed)
pka	8.84±0.20(Predicted)
Aggregatzustand	powder
Farbe	, faint yellow to dark orange

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	50/53
S-Sätze:	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

Gefahreninformationscode (GHS)

Y16 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität
Y16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.

in vitro

Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.

Cell Viability Assay

Cell Line:	NIH 3T3 cells
Concentration:	10 μΜ, 30 μΜ
Incubation Time:	24 hours
Result:	Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.

Western Blot Analysis

Cell Line:	NIH 3T3 cells
Concentration:	10 μΜ, 30 μΜ
Incubation Time:	24 hours
Result:	Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.

target

Y16 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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Target	Value
RhoGEFs ()