D609

Bezeichnung:D609

CAS-Nr83373-60-8

Englisch Name:D609

CBNumberCB9249743

SummenformelC11H17KOS2

Molgewicht268.47

MOL-Datei83373-60-8.mol

D609 physikalisch-chemischer Eigenschaften

storage temp.	0-6°C
Löslichkeit	H₂O: 300 mg/mL
Aggregatzustand	solid
Farbe	off-white
Wasserlöslichkeit	Soluble to 100 mM in water

Sicherheit

R-Sätze:	22
S-Sätze:	24/25
WGK Germany	3
HS Code	29333990

Gefahreninformationscode (GHS)

D609 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; K_i = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA₂, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC₅₀ = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
Chemische Eigenschaften
white to off-white solid
Verwenden
D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E^-/- mice.
Biologische Aktivität
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .
Biochem/physiol Actions
D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.
Lager
Desiccate at -20°C
Einzelnachweise
1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.

D609 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

83373-60-8, D609 Verwandte Suche:

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