5-AMINO-3-CHLOROPYRIDAZINE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P310：Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.

5-AMINO-3-CHLOROPYRIDAZINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  6-Chloro-4-pyridazinamine (cas# 29049-45-4) is a compound useful in organic synthesis.

• Application

  5-Amino-3-chloropyrazine, as an important structural unit of heterocyclic structures, possesses diverse chemical reactivity due to its pyrazine ring skeleton, chlorine atom, and amino functional group, making it a key intermediate for the synthesis of bioactive drug molecules and agrochemicals.

• Synthese

  

  1837-55-4

  

  29049-45-4

  General procedure for the synthesis of 6-chloro-4-amino pyridazine from 3,5-dichloropyridazine: 3,5-dichloropyridazine (1 g, 6.71 mmol, 1.0 eq.), ammonia (8 mL), and dioxane (2 mL) were added to a 25 mL round-bottom flask. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the resulting solid was collected by filtration. A final 570 mg (62% yield) of 6-chloro-4-aminopyridazine was obtained as a brown solid. The product was analyzed by LC-MS to confirm: (ES, m/z): retention time (RT) = 0.434 min, LCMS purity 53%, m/z = 130 [M + 1].

• Einzelnachweise

  [1] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 0941-0944

5-AMINO-3-CHLOROPYRIDAZINE Upstream-Materialien And Downstream Produkte

5-AMINO-3-CHLOROPYRIDAZINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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