2,4,7-TRINITRO-9-FLUORENONE Struktur

2,4,7-Trinitrofluoren-9-on

Bezeichnung:2,4,7-Trinitrofluoren-9-on

CAS-Nr129-79-3

Englisch Name:2,4,7-TRINITRO-9-FLUORENONE

CBNumberCB9210251

SummenformelC13H5N3O7

Molgewicht315.19

MOL-Datei129-79-3.mol

Synonyma

2,4,7-Trinitrofluoren-9-on

2,4,7-Trinitrofluoren-9-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	176-178°C
Siedepunkt	454.77°C (rough estimate)
Dichte	1.5148 (rough estimate)
Brechungsindex	1.5600 (estimate)
storage temp.	-20°C
Aggregatzustand	powder
Farbe	white
CAS Datenbank	129-79-3(CAS DataBase Reference)
EPA chemische Informationen	2,4,7-Trinitrofluoren-9-one (129-79-3)

Sicherheit

R-Sätze:	23/24/25-33
S-Sätze:	9-16-36/37/39
RIDADR	387
WGK Germany	3
HazardClass	1.1D
PackingGroup	II
Giftige Stoffe Daten	129-79-3(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 9910mg/kg

Gefahreninformationscode (GHS)

2,4,7-TRINITRO-9-FLUORENONE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R33:Gefahr kumulativer Wirkungen.
S-Sätze Betriebsanweisung:
S9:Behälter an einem gut gelüfteten Ort aufbewahren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
TNF-α influences the growth and function of both normal and neoplastic cells. TNF-α causes cytolysis or cytostasis of certain transformed cells being synergistic with γ-interferon in its cytotoxicity.
Verwenden
Tumor Necrosis Factor-α from mouse, a potent proinflammatory cytokine has been used:
- to activate MS1 endothelium cells
- to induce lipolysis in adipocytes
- to study its effect on liganded and unliganded glucocorticoid receptor (GR) in interleukin (IL)-6 and IL-8 gene regulation
Allgemeine Beschreibung
Pale yellow needles (from acetic acid or benzene) or yellow powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable. . Aromatic nitrates range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.
Hazard
Suspected carcinogen. Mildly toxic by ingestion. A skin and eye irritant.
Brandgefahr
Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable.
Biochem/physiol Actions
The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy
Sicherheitsprofil
Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Human mutation data reported. A skin and eye irritant. When heated to decomposition it emits hghly toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and KETONES.
läuterung methode
Crystallise it from nitric acid/water (3:1), wash it with water and dry it under vacuum over P2O5, or recrystallise it from dry *benzene. [Beilstein 7 II 410, 7 III 2348, 7 IV 1638.]

129-79-3, 2,4,7-TRINITRO-9-FLUORENONE Verwandte Suche:

Send Inquriy