QUISQUALIC ACID

Bezeichnung:QUISQUALIC ACID

CAS-Nr52809-07-1

Englisch Name:QUISQUALIC ACID

CBNumberCB9198500

SummenformelC5H7N3O5

Molgewicht189.13

MOL-Datei52809-07-1.mol

QUISQUALIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	185-187°C dec.
alpha	D20 +17.0° (c = 2.0 in 6M HCl)
Siedepunkt	324.36°C (rough estimate)
Dichte	1.6649 (rough estimate)
Brechungsindex	1.6190 (estimate)
storage temp.	2-8°C
Löslichkeit	NH₄OH 1 M: 20 mg/mL, clear, colorless
pka	2.12±0.10(Predicted)
Aggregatzustand	powder
Farbe	white to off-white
Wasserlöslichkeit	Soluble in ethanol, water. Insoluble in organic solvents.
Merck	13,8177
BRN	1078734
Stabilität	Stable. Incompatible with strong oxidizing agents.

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	26-36
WGK Germany	3
F	10

Gefahreninformationscode (GHS)

QUISQUALIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC₅₀s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; K_i = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.
Chemische Eigenschaften
Off-White Solid
Verwenden
Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.
Verwenden
An amino acid that is able to function as an agonist at multiple excitatory amino acid receptor substrates in the central nervous system. It also has high affinity for the kainate, AMPA and the metabotropic receptors. Inhibits the Ca2+/Cl-dependent glutamic acid uptake system in brain synaptic plasma membrane preparations.
Verwenden
Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.
Definition
ChEBI: Quisqualic acid is a non-proteinogenic alpha-amino acid.
Allgemeine Beschreibung
Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.
Biologische Aktivität
Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .
Biochem/physiol Actions
Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.
Lager
Store at RT
läuterung methode
It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].

QUISQUALIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

52809-07-1, QUISQUALIC ACID Verwandte Suche:

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