2-methyl-4-pyridinecarboxylic acid methyl ester

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-methyl-4-pyridinecarboxylic acid methyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  3998-90-1

  

  16830-24-3

  Methyl 2-chloro-6-methylpyridine-4-carboxylate (15.0 g, 80.8 mmol) was added with 10% palladium carbon catalyst (50% water, 5.00 g) and triethylamine (22.5 mL, 162 mmol) in N,N-dimethylformamide (200 mL). The reaction was stirred for 15 hours at room temperature under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography with the eluent ethyl acetate:methanol (100:0 to 50:1) to afford methyl 2-methylpyridine-4-carboxylate (14.8 g, 61% yield) as an oil.1H NMR (CDCl3) δ: 2.64 (3H, s), 3.95 (3H, s), 7.64 (1H, dd, J = 5.2, 0.8 Hz), 7.72 (1H, s), 8.65 (1H, d, J = 4.7 Hz).

• Einzelnachweise

  [1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 647 - 660
  [2] Patent: US5962458, 1999, A
  [3] Patent: US6362336, 2002, B1. Location in patent: Example 63
  [4] Helvetica Chimica Acta, 1955, vol. 38, p. 1046,1058
  [5] Bulletin de la Societe Chimique de France, 1958, p. 687,691

2-methyl-4-pyridinecarboxylic acid methyl ester Upstream-Materialien And Downstream Produkte

2-methyl-4-pyridinecarboxylic acid methyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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