Hexafluroniumbromid

hexafluronium bromide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Mylaxen,Mallinckrodt

• Verwenden

  Hexafluorenium Bromide is a cholinesterase inhibitor.

• Verwenden

  Relaxant (skeletal muscle); synergist (succinylcholine).

• Manufacturing Process

  2 Methods of producing of hexamethylene bis(2-fluorenyldimethylammonium) dibromide:
  1. To a solution of 13.2 g (0.054 mole) of 9-bromofluorene in 200 ml of acetonitrile was added 3.1 g (0.018 mole) of 1,6-bis(dimethylamino)hexane. Heat was evolved and solid began to precipitate immediately. After the initial reaction had subsided the mixture was refluxed for 3.5 h on a steam bath. The solid was collected and recrystallized three times from propanol to give 10.66 g (89% of the theoretical yield based on alkylenediamine) of hexamethylene bis(9-fluorenyldimethylammonium) dibromide, as white crystals melting at 188°-189°C.
  2. A mixture of 4.18 g (0.02 mole) of 2-dimethylaminofluorene and 1.22 g (0.005 mole) of 1,6-dibromohexane was heated at 115°C for 24 h, after which time 10 ml of dry dioxane was added and the mixture refluxed for an additional 37 h. The solid was filtered off washed with hot acetonitrile and twice recrystallized from propanol to give 0.45 g of hexamethylene bis(2- fluorenyldimethylammonium) dibromide, melting at 220°-222°C.

• Trademarks

  Mylaxen (Medpointe).

• Therapeutic Function

  Muscle relaxant

hexafluronium bromide Upstream-Materialien And Downstream Produkte

Hexafluroniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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