Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium

Bezeichnung:Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium

CAS-Nr12083-48-6

Englisch Name:Vanadinocene Dichloride

CBNumberCB8763194

SummenformelC10H10Cl2V10*

Molgewicht252.03

MOL-Datei12083-48-6.mol

Synonyma

Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium

Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium physikalisch-chemischer Eigenschaften

Schmelzpunkt	182-194 °C (dec.)(lit.)
Dichte	1,6 g/cm³
storage temp.	2-8°C
Löslichkeit	soluble in H2O, chloroform, ethanol
Aggregatzustand	crystal
Wichte	1.6
Farbe	green
Wasserlöslichkeit	Reacts with water
Sensitive	Air & Moisture Sensitive
Expositionsgrenzwerte	NIOSH: Ceiling 0.05 mg/m3
CAS Datenbank	12083-48-6(CAS DataBase Reference)
EPA chemische Informationen	Vanadocene dichloride (12083-48-6)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-28-36/37/39-45
RIDADR	UN 3285 6.1/PG 3
WGK Germany	3
RTECS-Nr.	YW1580000
HazardClass	8
PackingGroup	II
HS Code	29310099

Gefahreninformationscode (GHS)

Vanadinocene Dichloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
dark green crystalline powder
Verwenden
Bis(cyclopentadienyl)vanadium(IV) dichloride is a catalyst for solvent free, room temperature preparation of vicinal amino alcohols as fungistatic agents, catalyst fot oligomerization reactions via the Aufbau propagation reaction and as a catalyst for aqueous polymerization reactions using oxygen as a co catalyst. It is used as a catalyst for dl-selective pinacol-type coupling reactions, as an affecter of crystal growth of calcium carbonate and and as an inhibitor of human topoisomerase II enzyme with antitumor activity.
Verwenden
Vanadocene dichloride is used like other metallocenes as a catalyst, ultraviolet absorber, reducing agent, free radical scavenger, antiknock agent in gasoline, and as a developmental anticancer drug.
Allgemeine Beschreibung
Pale green crystals or green powder.
Air & Water Reaktionen
Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water
Reaktivität anzeigen
Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.
Brandgefahr
Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.
Pharmazeutische Anwendungen
Vanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing.
Pharmazeutische Anwendungen
Vanadocene dichloride [( η⁵-C₅H₅)₂VCl₂, dichloro bis(η⁵-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp₂TiCl₂. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp₂TiCl₂ because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.

Vanadinocene Dichloride Upstream-Materialien And Downstream Produkte

Dichlorobis(?5-cyclopenta-2,4-dien-1-yl)vanadium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

12083-48-6, Vanadinocene Dichloride Verwandte Suche:

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